Cough Suppressant and Expectorant

Cough Suppressant and Expectorant Image
Use 
To relieve coughs and chest congestion. 

METHOD 1 
Test Equipment 
Instrument: Viscometer or Rheometer 
Torque Range: RV 
Spindle: YULA-15E 
Accessories: Enhanced UL Adapter, 
TC-550AP Programmable Bath 
Speed: 50, 60, 70 ,80, 90, 100, 110, 120, 130, 140, 150, 160 and 170 RPM 
Temperature: 22°C 

Test Method 
We used a Brookfield DV3TRV Rheometer with Rheocalc™ software for automated instrument control and data acquisition. The temperature was regulated using an ULA-EY water jacket connected to a TC-550AP Refrigerated Programmable Bath. We ran three trials to determine repeatability. A syringe was used to measure and dispense 16 mL of the substance into the sample chamber. The spindle and chamber were cleaned before each trial, and fresh material was used in each trial. We equilibrated the sample, spindle and chamber for at least three minutes prior to testing. We ran our test in a speed ramp fashion. Using traditional RV speeds like 50 and 100 RPM can make a sufficient test for this type of material. However, since we used a DV3T Rheometer, we had the capability of running the test at a wide variety of speeds. Representative data from the analyses are shown in Figure 1. 

Figure 1 illustrates that both Brand A and Brand B are essentially Newtonian fluids. Newtonian fluids are characterized by a constant viscosity, independent of shear rate. Slight differences in viscosity over our range of shear rates can be accounted for by the 1% tolerance of the instrument. Figure 1 also shows that Brand A is more viscous than Brand B. 

Cough Suppressant and Expectorant Figure 1
Figure 1: Viscosity vs. Shear Rate 


METHOD 2 
Test Equipment 
Instrument: DV3T Rheometer 
Torque Range: LV 
Spindle: YULA-15E 
Accessories: Enhanced UL Adapter, TC-550AP Programmable Bath 
Speed: 3, 4, 5, 6, 7 ,8, 9, 10, 11, 12, 13, 14 and 15 RPM 
Temperature: 22°C 

Test Method 
We used a Brookfield DV3TLV Rheometer with Rheocalc™ software for automated instrument control and data acquisition. The temperature was regulated using an ULA-EY water jacket connected to a TC-550AP Programmable Bath. We ran three trials to determine repeatability. A syringe was used to measure and dispense 16 mL of the substance into the sample chamber. The spindle and chamber were cleaned before each trial, and fresh material was used in each trial. We equilibrated the sample, spindle and chamber for at least three minutes prior to testing. We ran our test in a speed ramp fashion. Using traditional LV speeds like 3, 6 and 12 RPM can make a sufficient test for this type of material. However, since we used a DV3T Rheometer, we had the capability of running the test at a wide variety of speeds. Representative data from the analyses are shown in Figure 2. 

Figure 2 illustrates that both Brand A and Brand B are essentially Newtonian fluids. Newtonian fluids are characterized by a constant viscosity, independent of shear rate. Slight differences in viscosity over our range of shear rates can be accounted for by the 1% tolerance of the instrument. Figure 2 also shows that Brand A is more viscous than Brand B. 

Cough Suppressant and Expectorant Figure 2
Figure 2: Viscosity vs. Rotational Speed






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